Search on: FACTOR VIII, THROMBIN-ACTIVATED 
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Descriptor English:   Factor VIIIa 
Descriptor Spanish:   Factor VIIIa 
Descriptor Portuguese:   Fator VIIIa 
Synonyms English:   Activated Factor VIII
Blood Coagulation Factor VIII, Activated
Coagulation Factor VIIIa
Factor 8A
Factor Eight A
Factor VIII, Activated
Factor VIII, Thrombin Activated
Factor VIII, Thrombin-Activated
Factor VIIIa Heavy Chain, 200 kDa Isoform
Factor VIIIa Heavy Chain, 92 kDa Isoform
Factor VIIIa Light Chain
Factor VIIIa, Coagulation
Thrombin-Activated Factor VIII  
Tree Number:   D12.776.124.125.350.300
D23.119.350.300
Definition English:   Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va. 
Entry Combination - descr/qualif English:   Factor VIIIa/deficiency use Hemophilia A
 
See Related English:   Coagulants
 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   24644 
Unique Identifier:   D015944 

Occurrence in VHL: 		 

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